Nanoplastic Polystyrene Particles Found to Pass through the Blood-Brain Barrier

According to the abstract of a April 19, 2023 Nanomaterials article by researchers with the Medical University of Vienna, Austria; Vassar College, New York; University of Debrecen, Hungary; Utrecht University, The Netherlands; and Vrije Universiteit Amsterdam, The Netherlands “… The blood–brain barrier (BBB) is an important biological barrier that protects the brain from harmful substances. In our study we performed short term uptake studies in mice with orally administered polystyrene micro-/nanoparticles … We show that nanometer sized particles—but not bigger particles—reach the brain within only 2 h after gavage … We found that the composition of the biomolecular corona surrounding the plastic particles was critical for passage through the BBB. Cholesterol molecules enhanced the uptake of these contaminants into the membrane of the BBB, whereas the protein model inhibited it. These opposing effects could explain the passive transport of the particles into the brain …” #PlasticWaste #SingleUsePlastic #MicroPlastics #NanoPlastics @MedUni_Wien