Microplastics – Toxicological Impacts of Exposure in Human Cells Examined

The abstract of a November 24, 2021 Journal of Hazardous Materials study https://doi.org/10.1016/j.jhazmat.2021.127861 by researchers with the UK University of Hull and University of Leeds reports that “… This review systematically synthesised all evidence and estimated thresholds of dose–response relationships … Seventeen studies were included in the rapid review and eight in the meta-regression. Four biological endpoints displayed MP-associated effects: cytotoxicity, immune response, oxidative stress, barrier attributes, and one did not (genotoxicity). Irregular shape was found to be the only MP characteristic predicting cell death, along with the duration of exposure and MP concentration (μg/mL). Cells showed varying cytotoxic sensitivity to MPs, with Caco-2 cells (human adenocarcinoma cell line) being the most susceptible. Minimum, environmentally-relevant, concentrations of 10 μg/mL (5–200 µm), had an adverse effect on cell viability, and 20 μg/mL (0.4 µm) on cytokine release. This work is the first to quantify thresholds of MPs effects on human cells in the context of risk assessment …” #MicroPlastics #NanoPlastics #PlasticWaste #SingleUsePlastic @HullYorkMed